Historically, scientists in training have learned the rules of ethical conduct by the example of their advisors and other senior scientists and by practice. This paper is intended to serve as a guide for the beginning scientist to some fundamental principles of scientific research ethics. The paper focuses less on issues of outright dishonesty or fraud, and more on the positive aspects of ethical scientific behavior; in other words, what a scientist should do to maintain a high level of ethical (...) conduct in research.There are a number of fairly specific rules, guidelines, or commonly accepted operating principles that have evolved for the ethical conduct of science. In order to discuss this code of ethics, this paper is divided into sections dealing with specific areas of scientific ethics. These areas are: data collection and storage, ownership of data, confidentiality, communication, authorship, collaboration, the peer review system, and rules of dealing with ethical complaints. Illustrative case histories are presented to provide examples of the type of ethical dispute or problem being discussed. If scientific trainees learn the accepted rules of behavior that govern the conduct of science, ethical problems that arise out of ignorance, misunderstanding, or poor communication can be avoided. (shrink)

The author is the recipient of the Herman Halperin Electric Transmission and Distribution Award, IEEE; United States Activities Board Professional Leadership Award, IEEE; United States Activities Board Citation of Honor, IEEE; Philip Sporn Award, Cigré; Atwood Associate, Cigré. J.A. Casazza has established the Peter Cooper Fund for Advancing Government Technical Competitions at Cooper Union.

Religion -- Metaphilosophy -- Marxism -- Global justice -- Nationalism.

Background: While advanced driver assistance technologies have the potential to increase safety, there is concern that driver inattention resulting from overreliance on these features may result in crashes. Driver monitoring technologies to assess a driver’s state may be one solution. The purpose of this study was to replicate and extend the research on physiological responses to common driving hazards and examine how these may differ based on driving experience.Methods: Learner and Licensed drivers viewed a Driving Hazard Perception Task while electrodermal (...) activity was measured. The task presented 30 Event and 30 Non-Event videos. A skin conductance response score was calculated for each participant based on the percentage of videos that elicited an SCR.Results: Analysis of the SCR score during Event videos revealed a medium effect of group differences, whereby Licensed drivers were more likely to have an SCR than Learner drivers. Interaction effects revealed Licensed drivers were more likely to have an SCR earlier in the Event videos compared to the end, and the Learner drivers were more likely to have an SCR earlier in the Non-Event videos compared to the end.Conclusion: Our results support the viability of using SCR during driving videos as a marker of hazard anticipation differing based on experience. The interaction effects may illustrate situational awareness in licensed drivers and deficiencies in sustained vigilance among learner drivers. The findings demand further examination if physiological measures are to be validated as a tool to inform driver potential performance in an increasingly automated driving environment. (shrink)

SummaryWilliam Barlow was an important if unconventional scientist, known for having developed the ‘closest-packing’ atomic models of crystal structure. He resumed an early nineteenth-century tradition of utilizing crystallographical and chemical data to determine atomic arrangements in crystals. This essay recounts Barlow's career and scientific activity in three parts: His place in the tradition of determining atomic arrangement in context of this earlier tradition and of contemporaneous developments of crystallography and chemistry, his unconventional career, and the ‘success’ of his program to (...) determine atomic arrangements in crystals and its influence on the work of William Lawrence Bragg. (shrink)

Michel Seymour | : Dans ce texte, j’examine sur un mode programmatique la relation qui existe entre les peuples et les territoires. Les frontières des peuples souverains sont-elles sacrées, naturelles et absolues, voire irréfragables ? Le territoire a-t-il une importance identitaire ? Si oui, cette relation identitaire repose-t-elle sur l’attachement sentimental des citoyens ou sur une préférence rationnelle ? Doit-on plutôt l’expliquer par un rapport historique ? Le territoire est-il un élément constitutif de l’identité d’un peuple ? Le principe (...) de l’intégrité du territoire a-t-il une priorité absolue sur le principe affirmant le droit à l’autodétermination des peuples ? Tel est l’éventail de questions qui peuvent être posées en ce qui concerne la relation entre les peuples et leurs territoires. Je veux présenter une perspective qui me semble être originale. Dans la perspective du libéralisme politique, je pars d’une conception institutionnelle du peuple. Je me propose d’indiquer ensuite comment cette approche permet d’envisager des réponses à ces questions. | : In this paper, I examine in a programmatic fashion the relationship between peoples and territories. Are the borders of sovereign peoples sacred, natural and absolute, or even irrebuttable ? Does territory plays an important role for identity ? If so, is this relationship based on the sentimental attachment of citizens or on a rational preference ? Should it be explained instead by a historical relationship ? Is territory even constitutive of the identity of a people ? Does the principle of territorial integrity have priority over the principle asserting the right to self-determination of peoples ? Such are the issues that can be raised concerning the relationship between peoples and their territories. I want to present an account that I take to be original. In accordance with political liberalism, I start from an institutional conception of peoples. I then indicate how this approach allows to consider answers to some of these questions. (shrink)

It was, until recently, accepted that the two classes of acetylcholine (ACh) receptors are distinct in an important sense: muscarinic ACh receptors signal via heterotrimeric GTP binding proteins (G proteins), whereas nicotinic ACh receptors (nAChRs) open to allow flux of Na+, Ca2+, and K+ ions into the cell after activation. Here we present evidence of direct coupling between G proteins and nAChRs in neurons. Based on proteomic, biophysical, and functional evidence, we hypothesize that binding to G proteins modulates the activity (...) and signaling of nAChRs in cells. It is important to note that while this hypothesis is new for the nAChR, it is consistent with known interactions between G proteins and structurally related ligand‐gated ion channels. Therefore, it underscores an evolutionarily conserved metabotropic mechanism of G protein signaling via nAChR channels.Also watch the Video Abstract. (shrink)

It was, until recently, accepted that the two classes of acetylcholine (ACh) receptors are distinct in an important sense: muscarinic ACh receptors signal via heterotrimeric GTP binding proteins (G proteins), whereas nicotinic ACh receptors (nAChRs) open to allow flux of Na+, Ca2+, and K+ ions into the cell after activation. Here we present evidence of direct coupling between G proteins and nAChRs in neurons. Based on proteomic, biophysical, and functional evidence, we hypothesize that binding to G proteins modulates the activity (...) and signaling of nAChRs in cells. It is important to note that while this hypothesis is new for the nAChR, it is consistent with known interactions between G proteins and structurally related ligand‐gated ion channels. Therefore, it underscores an evolutionarily conserved metabotropic mechanism of G protein signaling via nAChR channels.Also watch the Video Abstract. (shrink)

Une hypothèse fondamentale avancée par Searle et Vanderveken dans Foundations of Illocutionary Logic est que la force illocutionnaire est un élé;ment essentiel de la signification conventionnelle. La signification conventionnelle, qui est une propriété d'énoncé, s'oppose en gros ici à la signification intentionnelle, qui est une propriété prédiquée aux locuteurs. J'aimerais questionner certaines des motivations qui sont susceptibles de nous amener à accepter ce point de vue.

Book Three of George Santayana's letters covers a period of intense intellectual activity in Santayana's life, and the correspondence reflects the establishment of his mature philosophy. Santayana becomes more permanently established in Italy, but continues to travel in France, Spain, and England. The year 1927 marks the beginning of his long friendship with Daniel Cory, who became his literary secretary and eventually his literary executor. Also, with the death of Santayana's half-brother Robert, George Sturgis, Robert's son, becomes an important part (...) of Santayana's life and letters as his financial manager. Santayana continues to write to his sister Susana, as well as to numerous friends and fellow philosophers, including Bernard Berenson, Robert Seymour Bridges, Curt John Ducasse, John Erskine, Horace Meyer Kaller, Lewis Mumford, George Herbert Palmer, John Francis Stanley Russell, Herbert Wallace Schneider, Charles Augustus Strong, Paul Weiss, and Harry Austryn Wolfson. Other correspondents include Wendell T. Bush, Alys Gregory, Marianne Moore, John Middleton Murray, and Frederick J. E. Woodbridge. (shrink)

Since the first selection of George Santayana's letters was published in 1955, shortly after his death, many more letters have been located. The Works of George Santayana, Volume V, brings together a total of more than 3,000 letters. The volume is divided chronologically into eight books of roughly comparable length. Book Two covers Santayana's first decade as a "freelance philosopher," following his resignation from Harvard University and move to Europe. Of particular interest is Santayana's continuing correspondence with the American philosopher (...) Charles Augustus Strong and with his sister Susana Sturgis de Sastre. Also included is correspondence with such notable figures as Bertrand Russell, Robert Seymour Bridges, Horace Kallen, and Logan Pearsall Smith. The correspondence covers Santayana's resignation from Harvard, his time in England during World War I, and comments on his philosophical work during this period. (shrink)

Philosophers have proposed many accounts of biological function. A coarse-grained distinction can be made between backward-looking views, which emphasise historical contributions to fitness, and forward-looking views, which emphasise the current contribution to fitness or role of a biological component within some larger system. These two views are often framed as being incompatible and conflicting with one another. The emerging field of synthetic biology, which involves applying engineering principles to the design and construction of biological systems, complicates things further by adding (...) intentional design as a source of function. In the current study we explored how biology experts and novices think about function in the context of single-celled, multi-celled, and synthetic organisms. We also explored the extent to which each group were function pluralists, and if they were function pluralists, which accounts of function tended to be endorsed together. The results showed a surprising degree of similarity between experts and novices in most contexts, although certain differences were apparent. Most surprisingly, we found evidence not only of function pluralism in both groups, but pluralism between backward-looking and forward-looking accounts. We discuss these findings in the context of the philosophical debate on function and consider the practical implications for public acceptance of synthetic biology. First, we argue that philosophers of biology should re-examine the purported incompatibility between accounts of function. Second, we argue that due to the introduction of an intentional aetiology in synthetic biology, there may be an inherent conflict between the views of experts and novices when thinking about synthetic biology. (shrink)

Peace is a hallmark of human societies. However, certain ant species engage in long-term intergroup resource sharing, which is remarkably similar to peace among human groups. We discuss how individual and group payoff distributions are affected by kinship, dispersal, and age structure; the challenges of diagnosing peace; and the benefits of comparing convergent complex behaviours in disparate taxa.

Doctors’ strikes are legally permissible in the UK, with the situation differing in other countries. But are they morally permissible? Doug McConnell and Darren Mann have systematically attempted to dismiss the arguments for the moral impermissibility of doctors’ strikes and creatively attempted to provide further moral justification for them. Unfortunately for striking doctors, they fail to achieve this. Meanwhile, junior doctors’ strikes have continued in the UK through 2023 and have now extended into 2024. In this response, which focuses on (...) the UK situation and specifically junior doctors’ strikes in the National Health Service (NHS) in England, I will demonstrate a central problem with their arguments—namely that they underplay the harms caused by prolonged doctors’ strikes by ignoring the harms to patients with cancer. This weakens their conclusion that strikes are morally permissible in terms of the conditions and thresholds they set. I then provide a psychological critique of their justification for strikes in terms of the interests of the public. It follows that invoking the controversial concept of supererogatory action is ungrounded but also absurd when you consider time-critical cancer care. If those representing striking doctors wish to maintain a modicum of moral respectability, they should mitigate for patients with cancer and negotiate reasonably and with urgency. (shrink)

Building Better Health Care Leadership for Canada explains the development and implementation of the Executive Training in Research Application program. Managed and funded by the Canadian Health Services Research Foundation in partnership with the Canadian Medical Association, the Canadian Nursing Association, and the Canadian College of Health Care executives, EXTRA is a two-year national fellowship program that uses the principles of adult learning theory as well as practical projects to educate senior health care leaders in making more consistent use of (...) research evidence in their management roles. Fellows apply the theory learned in residency sessions and educational activities to projects within their home organizations. The authors identify the imperative for better use of evidence, outline the core elements of the curriculum, and capture the real-world experience of regional leaders and fellows involved in making specific changes informed by research-based evidence within their organization. Contributors include Jean-Louis Denis, Terrence Sullivan, Owen Adams, Malcolm Anderson, Lynda Atack, Robert Bell, Sam G Campbell, Sylvie Cantin, Ward Flemons, Dorothy Forbes, J. Sonja Glass, Paula Goering, Karen Golden-Biddle, Jeffrey S. Hoch, Paul Lamarche, Ann Langley, John N. Lavis, Jonathan Lomas, Margo Orchard, Raynald Pineault, Brian D. Postl, Christine Power, Trish Reay, Jean Rochon, Denis A. Roy, Andrea Seymour, Samuel B. Sheps, Micheline Ste-Marie, Nina Stipich, David Streiner, Carl Taillon, and Muriah Umoquit. (shrink)